This transmittal provides notice of coverage and reimbursement for Monoclonal Antibody infusions in the professional fee schedule for fee-for-service providers that bill HCPCS and CPT codes on CMS-1500 claim forms, and for providers enrolled in Medicaid Managed Care Organization (MCO) networks. This transmittal amends guidance provided in Transmittal #21-33 COVID-19 Monoclonal Antibody Infusions Update issued August 11, 2021.